Select Biosciences Ltd
Genzyme and Medicines for Malaria Venture Announce new Collaboration with Advinus Therapeutics
The collaboration is aimed to accelerate discovery of improved treatments for specific patient groups most at risk for malaria.
Dyax and AVEO Pharmaceuticals Announce Antibody Library License Agreement
Dyax has granted AVEO a non-exclusive license to its proprietary antibody phage display libraries for the discovery and development of therapeutic antibodies.
Clinical-Scale Generation of Functional Red Blood Cells from Human Embryonic Stem Cells
ACT reports that it is feasible to differentiate and mature hESCs into functional oxygen-carrying RBCs under conditions suitable for scale-up.
AstraZeneca Announces Partnership with Singapore Institutions to Develop Anti-Cancer Compounds
The collaboration aims to further build AstraZeneca's drug development capabilities in Asia and speed up access to new medicines of potential benefit to patients.
Hyperbaric Bioreactors use with Yarrowia Lipolytica Cultures: Cellular Adaptation to Hyperbaric Conditions
IBB-Institute for Biotechnology and Bioengineering, Center of Biological Engineering, University of Minho, Braga, Portugal

In this work, a pressurized bioreactor was used for Y. lipolytica batch cultivation under increased air pressure from 1 bar to 6 bar. Cell growth was strongly enhanced by the pressure rise. The increase of oxygen availability caused the induction of the antioxidant enzyme SOD. The pre-growth of Y. lipolytica under increased pressure conditions did not affect the lipase production ability of the cells.
Adaptive control of glycerol & methanol feeding in recombinant Pichia pastoris cultures: Impact on antibody titre
CQFB/REQUIMTE and IBET/ITQB

Pichia pastoris processes for heterolougous protein expression are typically run in three phases: a batch phase, an exponential feeding fed-batch phase and a long oxygen transfer limitation (OTL) phase. The final protein titre is often limited by the oxygen availability in the OTL phase. Here a direct adaptive controller is designed for the OTL phase. The controller was validated in pilot P. pastoris cultivations expressing a single chain antibody fragment (ScFv). This work shows that the propos
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World Drug Manufacturing Summit, Dusseldorf, Germany
09 September 2008 - 11 September 2008

The World Drug Manufacturing Summit brings together the leading pharmaceutical and biotech manufacturing professionals to network and discuss issues at the cutting edge of lean production methods and transformational change in a tightly regulated environment.
To view the full programme and to register, visit the website http://www.wdmsummit.com or call +44 (0) 207 202 7558
Operational Excellence in Pharmaceutical and Medical Devices, London, UK
15 October 2008 - 16 October 2008

Announcing the return of Pharma IQ’s Operational Excellence in Pharmaceuticals & Medical Devices! Back for its 3rd year, the conference will provide an unrivalled platform for learning from key case studies and the latest developments within the industry.
  
Compound Management Trends 2008
Published July 2008

This market report summarizes the results of HTStec’s second global pharma and biotech web-based benchmarking survey on compound management carried out in January 2008.

The study was initiated to gain a better awareness of the metrics behind current and future compound management (CM) practices within pharmaceutical, biotech and other life science research establishments. The survey focus was on liquid stores, with particular emphasis on learning how the makeup of corporate compound collectio
Cleaning Microreactors
This application note gives hints and tips on cleaning & unblocking flow reactors, i.e. chips or tube based reactors. It is suggested that the whole document is read before attempting to unblock a reactor. more>>>